高盐饮食增加了通过内分泌素受体B型信号传递的上性神经刺激性
Jodi R Paul1, Megan K Rhoads2, Anna Elam1
1Division of Behavioral Neurobiology, Department of Psychiatry, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA.
Function (Oxford, England)
|March 5, 2025
概括
高盐饮食通过影响大脑上神核 (SCN) 中的内甲蛋白B (ETB) 受体来破坏昼夜节律. 这影响了分泌和神经元活动,揭示了饮食和生理时钟之间的新联系.
科学领域:
- 神经科学是一个神经科学.
- 时间生物学 时间生物学
- 生理学 生理学 生理学
背景情况:
- 循环节律调节日常的生物过程,包括血压和分泌.
- 内甲素B (ETB) 受体与周围生理时钟功能和调节有关,特别是在高盐饮食中.
- 尽管ETB受体存在于SCN天体细胞中,但ETB受体在大脑主昼夜节律节律器SCN中的作用仍然在很大程度上未被探索.
研究的目的:
- 通过ETB受体,研究高盐饮食对昼夜系统的影响.
- 检查高盐摄入对小鼠昼夜节律的行为,分子和生理影响.
- 阐明ETB信号在SCN对食的反应中的作用.
主要方法:
- C57BL/6小鼠被食高盐饮食 (4.0%NaCl) 两个星期.
- 监测轮子运行活动以评估行为变化.
- 光在位杂交和松散补丁电生理学被用于分析SCN ETB mRNA表达和神经元刺激性.
- 活体实验涉及应用ETB抗剂和内甲素-3,有或没有NMDA受体抗剂.
主要成果:
- 高盐饮食改变了夜间的轮子运行活动模式.
- 在高盐饮食的小鼠中,SCN ETB mRNA表达和神经元刺激性在夜间增加.
- ETB受体对抗性改善了高盐饮食诱导的SCN过活性,而内甲素-3模仿了这些效应.
- 内甲素-3的刺激作用被一个NMDA受体对抗剂阻断,表明谷氨酸中介作用.
结论:
- 功能性ETB受体存在于SCN天体细胞中.
- 内脏蛋白信号传递在调解SCN对摄入量的神经元反应方面发挥着新的作用.
- 饮食盐摄入量可以通过SCN中的ETB受体通路影响昼夜节律.
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