更年期症状负担作为中晚年认知功能和轻度行为障碍症状的预测指标:一项CAN-PROTECT研究
Jasper F E Crockford1,2, Dylan X Guan1,3,4, Gillian Einstein5,6
1University of Calgary, Calgary, AB, Canada.
PloS one
|March 5, 2025
概括
更年期症状负担增加与更糟糕的认知功能和更轻微的行为障碍 (MBI) 症状在更年期后的妇女有关. 激素治疗可能有助于减少MBI症状.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 妇女健康 妇女健康
背景情况:
- 新兴证据将更年期症状与认知和行为变化联系起来.
- 这项研究侧重于绝经后的女性,以调查这些关联.
研究的目的:
- 检查更年期症状负担和认知功能之间的关系.
- 调查绝经后妇女更年期症状负担和轻度行为障碍 (MBI) 症状之间的关联.
主要方法:
- 从CAN-PROTECT研究中参与896名绝经后妇女的横截面观察研究.
- 更年期症状负担由总回忆的更年期周围症状评估.
- 用日常认知 (ECog-II) 尺度测量认知功能;使用轻度行为障碍检查清单 (MBI-C) 评估MBI.
- 使用负二项式和零膨胀负二项式回归模型,对包括年龄和激素治疗 (HT) 在内的共变量进行调整.
主要成果:
- 更年期更重的症状负担与更高的ECog-II得分 (认知能力较差) 和更高的MBI-C得分 (更多的MBI症状) 相相关.
- 激素治疗 (HT) 与较低的MBI-C得分有显著的关联,这表明对行为变化有潜在的缓解作用.
结论:
- 更年期症状负担与认知功能下降和中晚年妇女MBI症状增加有关.
- 激素治疗可能在缓解绝经后的MBI症状中发挥作用.
- 这些发现强调更年期是对认知和行为变化敏感性的潜在指标,这是痴呆症的标志物.
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