在希腊,通过体积计算机断层扫描进行肺癌查是具有成本效益的
Xuanqi Pan1,2, Katerina Togka1, Hilde Ten Berge1
1Institute for Diagnostic Accuracy, Groningen, The Netherlands.
PloS one
|March 5, 2025
概括
使用低剂量计算机断层扫描 (LDCT) 的肺癌查在希腊非常具有成本效益. 这种方法可以识别早期癌症,避免死亡,并改善高风险个体的健康结果.
科学领域:
- 公共卫生 公共卫生
- 卫生经济学 卫生经济学
- 在瘤学瘤学.
背景情况:
- 肺癌仍然是全球主要的死亡原因.
- 早期检测显著改善了患者的治疗结果和生存率.
- 确定具有成本效益的查策略对于医疗保健系统的资源配置至关重要.
研究的目的:
- 用基于体积的低剂量计算机断层扫描 (LDCT) 评估肺癌查 (LCS) 的成本效益.
- 在希腊的一个无症状高风险人群中,将LCS与没有查进行比较.
- 为了利用欧洲NELSON研究的数据进行建模.
主要方法:
- 一个验证的决策树和马尔科夫模型从医疗保健支付者的角度模拟了结果.
- 该模型预测了肺癌检测,诊断,治疗成本,寿命年 (LYs) 和质量调整寿命年 (QALYs).
- 进行了敏感性和场景分析,以确保模型的稳定性.
主要成果:
- 年度LCS与基于体积的LDCT在207,885个人中确定了17104例早期肺癌.
- 这种查策略避免了8,761例过早死亡,获得了86,207例LY和50,207例增量QALY.
- 增量成本效益比 (ICER) 为每LY3236欧元,每QALY5505欧元.
结论:
- 基于体积的LDCT的肺癌查对希腊的高风险人口来说非常具有成本效益.
- 实施LCS优化了公共医疗保健资源分配.
- LCS提供了显著的临床益处,并改善了肺癌患者的治疗结果.
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