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Updated: May 24, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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错误拼接导致p53E224D点突变的功能丧失

Ian C Lock1, Nathan H Leisenring2,3, Warren Floyd1,4

  • 1Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America.

PloS one
|March 5, 2025
PubMed
概括

矛盾的是,在人类癌症中发现的一种特定的p53突变,导致拼接变异,导致瘤抑制功能丧失. 这导致瘤发育的增加和小鼠的寿命缩短.

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