相关实验视频
Updated: May 24, 2025
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
直接从碳酸酸中快速和可扩展的合成氧醇
Lahu N Chavan1, Gouthami Pashikanti1, Mark M Goodman2
1Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322.
一种新方法通过使用trifyllpyridinium试剂从碳酸中合成4,5-非替代性氧化. 这种高效的过程是多用途的,适用于药物合成和功能化生物活性分子,具有可回收的催化剂.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
背景情况:
- 在药物化学中,对氧化等异环化合物的高效合成至关重要.
- 目前用于合成奥克萨的现有方法通常需要恶劣的条件或专门的试剂.
研究的目的:
- 开发一种新,高效,多用途的方法,直接从碳酸盐中合成4,5-非替代性氧醇.
- 为了证明新方法在合成有价值的化合物和功能化生物活性分子中的广泛适用性.
主要方法:
- 使用稳定的trifyllpyridinium试剂直接将碳酸转化为4,5-非替代的氧化.
- 反应通过在位生成的酸盐中间体进行,被异酸盐或托西尔甲基异化物捕获.
- 研究的基质范围,功能组耐受性和可扩展性,包括DMAP基础的恢复和再利用.
主要成果:
- 实现了具有广泛基质范围和良好的功能组耐受性的4,5-异位氧醇的高效和方便的合成.
- 成功地将该方法应用于5 - 氨基联氨酸 (5-ALA) 的グラム级合成和雌激素,脂酸,酸和酸的晚期功能化.
- 证明了实用的好处,包括DMAP催化剂的回收和再利用.
结论:
- 开发的以trifyllpyridinium为媒介的合成提供了一种实用且多功能的途径,可以获得4,5-非替代性氧化醇.
- 这种方法适用于合成制药化合物和修改复杂的生物活性分子.
- 反应的效率,功能组耐受性和催化剂可回收性突出显示了其广泛应用的潜力.
更多相关视频
10:42Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
Published on: June 20, 2014
相关概念视频
Preparation of Carboxylic Acids: Overview
Preparation of Carboxylic Acids: Hydrolysis of Nitriles
Preparation of Aldehydes and Ketones from Carboxylic Acid Derivatives
Carboxylic acid derivatives like acid chlorides and esters are more easily reducible than the corresponding acids. The derivatives reduce in the presence of mild reducing agents to give aldehydes. Aldehydes can also be prepared by Rosenmund reduction, that is, the reduction of...
Preparation of Amides
The DCC-promoted synthesis of amides begins with the protonation of DCC by carboxylic acid. The protonation makes it a better acceptor. Next, the addition of carboxylate to the protonated carbodiimide gives a reactive acylating agent.
Subsequently, the amine acts as a nucleophile that attacks the acylating agent to form a tetrahedral intermediate. In the...
Preparation of Carboxylic Acids: Carboxylation of Grignard Reagents
Alkylation of β-Diester Enolates: Malonic Ester Synthesis