体质指数与脑内出血相关的功能衰退之间的U形关系
Yuji Kanejima1,2, Masato Ogawa1,3,4, Kodai Ishihara1,5
1Department of Public Health, Graduate School of Health Sciences, Kobe University, Hyogo, Japan.
Neurological research
|March 5, 2025
概括
保持健康的体重指数 (BMI) 在脑内出血 (ICH) 后至关重要. 体重指数在22.2-30.4 kg/m2之间与ICH幸存者的功能衰退较低有关.
科学领域:
- 神经学 神经学
- 公共卫生 公共卫生
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 身体质量指数 (BMI) 被认为是影响脑内出血 (ICH) 结果的因素.
- 精确的BMI范围,使ICH后的功能下降降至最低,仍然未确定.
- 了解最佳的BMI对于改善患者康复和长期预后至关重要.
研究的目的:
- 调查体质指数 (BMI) 与脑内出血 (ICH) 后患者的功能衰退之间的关联.
- 确定一个最佳的BMI范围,可以减少ICH后功能下降的风险.
- 为ICH幸存者提供基于证据的BMI管理建议.
主要方法:
- 利用了来自日本所有心血管疾病诊断程序组合 (JROAD-DPC) 数据库的数据 (2016年4月 - 2020年3月).
- 包括155211名被诊断患有ICH的患者.
- 使用世界卫生组织亚太地区分类对BMI进行分类,并通过修改的兰金尺度 (mRS) 评分变化评估功能衰退.
主要成果:
- 总共分析了155211名ICH患者,平均BMI为22.3公斤/米2.
- 超过74%的患者在ICH后经历了功能衰退.
- 超重的BMI类别 (23.0 < BMI ≤ 25.0 kg/m2) 显示了功能衰退率最低的情况 (OR:0.90,95% CI:0.85-0.94).
- 一个U形曲线表明,BMI在22.2-30.4 kg/m2之间与功能衰退的几率降低有关.
结论:
- 体重不足和超重的BMI都与ICH后功能衰退的增加有关.
- 保持BMI在22.2-30.4kg/m2范围内,可能有助于减轻ICH幸存者的功能衰退.
- 这一发现支持有针对性的BMI管理策略,以改善从脑内出血中恢复过来的个体的结果.
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