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脑流α-synuclein聚合与APOE ε4和阿尔茨海默氏病的渐进性认知衰退有关

Qiang Qiang¹, Loren Skudder-Hill², Tomoko Toyota³

¹Department of Neurology, Cognitive Disorders Center, Huadong Hospital, Fudan University, Shanghai, China; Department of Neurology, University of Occupational and Environmental Health School of Medicine, Kitakyushu, Japan.

Neurobiology of aging

|March 5, 2025

概括

大脑脊髓液 (CSF) 的α-synuclein聚合在阿尔茨海默氏症中更为常见.

科学领域:

神经科学是一个神经科学.
生物标志物生物标志物
神经退行性疾病神经退行性疾病

背景情况:

勒维体病理,以α-synuclein聚合物为特征,在大约一半的阿尔茨海默病 (AD) 大脑中发现.
研究大脑脊髓液 (CSF) 中的α-synuclein聚合可以提供有关AD进展的见解.

研究的目的:

为了确定认知正常 (CN),轻度认知障碍 (MCI) 和AD痴呆症个体中CSFα-synuclein聚合的患病率.
检查CSFα-synuclein聚合,人口因素 (APOE ε4状态) 和认知衰退之间的关联.

主要方法:

使用种子放大试验 (SAA) 来检测CSF样本中的α-synuclein聚合.
分析了来自1619名阿尔茨海默病神经成像计划 (ADNI) 队列的参与者的数据.
与认知状态和APOE ε4载体状态相关联的CSFα-synuclein聚合状态.

主要成果:

积极的CSFα-synuclein聚合在AD痴呆症 (37.07%) 和MCI (22.75%) 组中比CN对照 (16.13%) 更为普遍.
APOE ε4载体显示出α-synuclein聚合的更高流行率.
积极的CSFα-synuclein聚合与MCI和AD痴呆症组的加速认知衰退有关,特别是在APOE ε4载体中.

结论:

脑流α-synuclein聚合与认知障碍和AD中的APOE ε4状态有关.
与APOE ε4状态相结合的CSFα-synuclein SAA可能作为AD认知衰退的预测生物标志物.

关键词:

在APOE4OE4中使用.阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.在CSF生物标志物中.种子放大试验试验.α-synuclein 是一种同核蛋白.

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