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通过大气中的PM_2.5颗粒对 Estrogen 的健康风险评估:苏州的一个案例研究

Minhao Wang¹, Dongling Li², Ting Tong²

¹Department of Health and Environmental Sciences, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China; Department of Chemistry, School of Physical Science, University of Liverpool, Liverpool, UK.

Ecotoxicology and environmental safety

|March 5, 2025

概括

像BPA这样的大气中的异性雌激素对健康构成风险,特别是对儿童. 这项研究监测了PM2.5中的六种异性雌激素,发现冬季度更高,对幼儿的风险更高.

科学领域:

环境科学环境科学
公共卫生公共卫生
毒理学毒理学毒理学

背景情况:

异雌激素是大气颗粒 (PM2.5) 中发现的内分泌干扰物.
吸入暴露会导致不良健康影响,包括癌症和发育问题.
了解异雌激素的分布和对健康的影响对于公共卫生政策至关重要.

研究的目的:

分析大气PM2.5.5中的六种目标异性雌激素的月度分布,季节变化和健康影响.
评估与异性雌激素暴露相关的非致癌和致癌风险.
为了确定易受大气中的异性雌激素暴露的脆弱人群.

主要方法:

从2021年9月到2023年9月收集和分析大气PM2.5样本.
六种异性雌激素的定量度:BPA,DBP,DEHP,DIBP,NP,以及4-t-OP.
计算不同年龄组的非致癌 (危险指数) 和致癌 (增量终身癌症风险) 风险.

主要成果:

每月平均的异性雌激素度为20 ng·m−3,PM2.5度从1.75到217.36 μg·m−3.3不等.
双A (BPA) 是占主导地位的外雌激素,其峰值为126.52 ± 0.67 ng·m−3.3.
冬季的异性雌激素度 (BPA,DBP,DEHP) 比夏季高得多;婴儿和幼儿面临更高的风险 (HI和ILCR).

结论:

虽然整体人口风险低于值,但婴儿和幼儿暴露于大气中的异性雌激素的风险明显更高.
异性雌激素水平的季节性变化很明显,特别是冬季度更高.
调查结果为制定政策提供了关键数据,以减轻大气中异性雌激素的健康风险.

关键词:

非饮食暴露的非饮食暴露.在PM中{2.5)季节性变化季节性变化来源贡献的贡献来源.这是一种异性雌激素.

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