植物细胞循环调节者控制病毒病原体的核环境
Xu Zhang1, Ge Wang1, Peng Zhang1
1College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An 271018, Shandong, China.
Cell host & microbe
|March 5, 2025
概括
病毒劫持番茄的病毒
科学领域:
- 植物病毒学 植物病毒学
- 分子植物病理学 分子植物病理学
- 细胞周期调节细胞周期调节
背景情况:
- 细胞循环调节器对于病毒复制和植物生长至关重要.
- 在宿主病毒相互作用中,RETINOBLASTOMA-RELATED 1 (RBR1) 和E2F转录因子之间的相互作用尚未完全理解.
研究的目的:
- 阐明病毒操纵番茄RBR1-E2F复合物的机制.
- 了解这种操纵如何影响宿主植物生长和病毒传播.
主要方法:
- 研究了番茄的亚纳相促进复合体/环体 (APC/C) 激活剂CDC20和RBR1.1之间的相互作用.
- 分析了APC/CCDC20在调节RBR1和cyclin D1水平中的作用.
- 检查了病毒策略来重新利用APC/C活动.
主要成果:
- 番茄APC/CCDC20与RBR1结合或消耗D1环素,从而保留RBR1-E2F复合体.
- 双子病毒和克里尼病毒操纵APC/CCDC20以降低RBR1或阻断环林D1,释放E2Fs.
- 释放的E2Fs激活病毒复制基因 (DNA聚合酶,HSP70).
- 破坏RBR1-E2F复合体导致宿主生长抑制.
结论:
- 病毒利用宿主的APC/CCDC20来控制RBR1-E2F复合体,以便自己复制.
- 这种病毒策略破坏了宿主细胞循环调节,有利于病毒传播,以牺牲植物活力为代价.
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