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Updated: May 24, 2025

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
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生殖系变异和马赛克染色体变异影响COVID-19疫苗免疫性

Kyuto Sonehara1, Yoshifumi Uwamino2, Ryunosuke Saiki3

  • 1Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Cell genomics
|March 5, 2025
PubMed
概括

遗传因素显著影响疫苗反应. 这项研究将免疫球蛋白重链 (IGH) 和主要基因相容性复合体 (MHC) 中的特定基因变异与COVID-19疫苗接种后的抗体水平联系起来. 身体突变也会影响免疫功能.

关键词:
这是COVID-19疫苗.格雷夫斯的疾病.克隆性血液形成 (clonal hematopoiesis) 是一种细胞形成的过程.全基因组关联研究研究.免疫性 免疫性 免疫性免疫球蛋白重链免疫球蛋白重链免疫球蛋白主要的组织相容性复杂.马赛克染色体改变马赛克丢失的X染色体X染色体.马赛克丢失的染色体Y的染色体Y.这是一种血症.

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