在中国的CTX-M型扩展谱β-乳糖酶的传播:流行病学和进化分析
Keyi Yu1, Zhenzhou Huang2, Xiao Liu3
1Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310005, China.
The Journal of infection
|March 5, 2025
概括
CTX-M型扩展光谱β-乳糖酶 (ESBLs) 在全球传播. 这项研究分析了中国的blaCTX-Ms,揭示了CTX-M-1和CTX-M-9作为主要的子组,并突出了人类活动.
科学领域:
- 微生物学 微生物学
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- CTX-M型扩展光谱β-乳糖酶 (ESBLs) 呈现广泛的全球传播.
- 对中国的ESBL流行病模式的系统理解仍然有限.
- blaCTX-Ms是对抗菌素耐药性的重要贡献者.
研究的目的:
- 在中国全面分析blaCTX-Ms的流行病学和进化特征.
- 为了研究blaCTX-Ms的基因型多样性和家族遗传模式.
- 评估地理因素和人类活动对blaCTX-Ms进化的影响.
主要方法:
- 对来自中国25个城市的4146种细菌菌株 (1974-2023) 和431种公共数据库菌株的分析.
- 遗传学研究以确定占主导地位的CTX-M亚组,并分析突变部位.
- 计算Ka/Ks比率以确定不同血统的选择压力.
主要成果:
- 确定了133个 (3.2%) 的 blaCTX-Ms生产菌株,其中CTX-M-1和CTX-M-9作为主要的子组.
- 临床隔离主要与腹,上呼吸道和尿路感染有关.
- 血统表现出多样化的进化模式,L3血统在地理上受到人类活动的重大影响.
结论:
- blaCTX-Ms在中国表现出多样化的基因型和进化特征.
- 遗传学分析揭示了不同的选择压力和血统内的适应性进化.
- 这些发现支持在中国加强对 blaCTX-Ms的健康风险评估和预警系统.
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