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Updated: May 24, 2025

Author Spotlight: Unveiling the Role of SNF2L in Replication Fork Stability and Genome Duplication
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Author Spotlight: Unveiling the Role of SNF2L in Replication Fork Stability and Genome Duplication

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DDX37和DDX50通过防止转录依赖的R循环形成来保持基因组稳定性

Yeray Hernández-Reyes1, Cintia Fonseca-Rodríguez1, Raimundo Freire2

  • 1Unidad de Investigación, Hospital Universitario de Canarias, Instituto de Investigación Sanitaria de Canarias (IISC), Santa Cruz de Tenerife, Spain; Instituto de Tecnologías Biomédicas, Universidad de La Laguna, Santa Cruz de Tenerife, Spain; Escuela de Doctorado y Estudio de Postgrado, Universidad de la Laguna, Santa Cruz de Tenerife, Spain.

Journal of molecular biology
|March 5, 2025
PubMed
概括

新的研究确定DDX37和DDX50是关键的RNA螺旋酶,在转录过程中分解RNA-DNA杂交物. 它们的枯竭会导致DNA损伤和复制压力,突出显示它们在维持基因组稳定性方面的作用.

关键词:
这是DDX DDX DDX造成的DNA损伤是DNA损伤.在R-Loop中使用.螺旋酶是指螺旋酶的组成部分.转录 转录 是一种转录.

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