在中国的监管限制下食肉的肉中,阿弗拉托克辛B和泽拉伦之间没有毒性作用或相互作用
Wanjun Zhang1, Yongpeng Jin1, Ying Liu1
1State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, PR China.
Regulatory toxicology and pharmacology : RTP
|March 5, 2025
概括
中国目前对动物料的真菌毒素限制值可能需要修订. 研究表明,在这些水平上,亚黄素B1 (AFB1) 和泽拉伦 (ZEA) 不会影响肉的健康,这表明需要进一步调查的综合效应.
科学领域:
- 动物营养 动物营养
- 毒理学 毒理学 毒理学
- 食品安全 食品安全
背景情况:
- 目前动物料中的真菌毒素法规侧重于单一污染物.
- 同时污染很普遍,可能导致添加剂有毒效应.
- 中国已经为动物料中的六种主要真菌毒素制定了监管限制.
研究的目的:
- 评估在中国监管限制下单独和组合的阿弗拉托克辛B1 (AFB1) 和泽拉伦 (ZEA) 对肉的影响.
- 评估对生长,氧化应激,血清生物化学,免疫和器官组织病理学的影响.
主要方法:
- 432只一天大的雄性AA肉被分为四个组:对照组,AFB1,ZEA和联合AFB1+ZEA.
- 菌毒素在中国的监管限值 (10微克/千克 AFB1,500微克/千克 ZEA) 进行了35天的治疗.
- 评估了生长性能,氧化应激标志物,血清生物化学,免疫指标,肠道形态学和肝/组织病理学.
主要成果:
- 在治疗组之间没有观察到生长性能,氧化应激标志物,血清生物化学或细胞因子水平的显著差异.
- 肠道健康和肝脏和脏的组织病理学评估没有显示任何不良影响.
- 在测试度下,没有检测到AFB1和ZEA之间的有毒相互作用.
结论:
- 该研究表明,目前中国对AFB1和ZEA的监管限制,单独或组合,不会显著影响肉的健康参数.
- 建议进行进一步的研究,以调查更广泛的真菌毒素的综合毒理效应.
- 这些发现可能有助于修订和制定更全面的动物料安全标准.
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