补充氧气用于严重呼吸系统疾病患者的症状缓解:系统性审查和元分析
Zainab Ahmadi1, Natasha E Smallwood2,3, Anne-Marie Russell4,5
1Respiratory Medicine, Allergology and Palliative Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden zai.ahmd@gmail.com.
补充氧气疗法有效地减少严重呼吸系统疾病的运动期间的喘息. 然而,它并没有改善日常生活的呼吸困难或生活质量,证据的确定性很低.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 临床试验 临床试验
- 生活质量研究 研究 生命质量研究
背景情况:
- 严重的呼吸道疾病往往会导致显著的症状负担.
- 补充氧气治疗旨在缓解呼吸困难并提高与健康有关的生活质量 (HRQoL).
研究的目的:
- 系统地审查和对氧疗法与无氧疗法的有效性进行元分析.
- 评估对呼吸困难,HRQoL和不良事件的影响.
主要方法:
- 对控制试验的Embase,Medline和Cochrane中央注册表进行全面搜索,截至2022年6月.
- 使用随机效应元分析和建议评级,评估,开发和评估 (GRADE) 框架.
- 标准化平均差异 (SMDs) 聚合以量化影响.
主要成果:
- 氧气治疗减少了实验室炼期间的呼吸困难 (SMD -0.75).
- 没有观察到对日常生活呼吸困难 (SMD -0.08) 或HRQoL (SMD -0.06) 的显著影响.
- 报告的不良事件很少;所有结果的证据确定性都很低.
结论:
- 氧气疗法在受控的炼环境中改善了炼性呼吸困难.
- 证据不支持改善日常生活的呼吸困难或HRQoL.
- 由于证据的确定性较低,需要进一步研究.
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