使用呼出的挥发性有机化合物开发结肠直肠癌预测模型
Se-Jin Baek1, Hosub Lim2, Selim Oh2
1Division of Colon and Rectal Surgery, Department of Surgery, Korea University College of Medicine, Seoul, South Korea.
Diseases of the colon and rectum
|March 5, 2025
概括
诊断结肠直肠癌可能很快就可能使用呼出的呼吸. 这项研究开发了一种结合挥发性有机化合物 (VOC) 和临床数据的预测模型,在区分患者和健康个体方面实现了高准确性.
科学领域:
- 生物标志物和诊断方法
- 呼吸系统医学 呼吸系统医学
- 在瘤学瘤学.
背景情况:
- 结肠直肠癌 (CRC) 诊断缺乏非侵入性和高效的标志物.
- 呼出的气息中的挥发性有机化合物 (VOC) 是有前途的疾病指标.
研究的目的:
- 使用呼出的VOC建立结直肠癌 (CRC) 诊断的预测模型.
- 确定特定的VOC和临床变量,以区分CRC患者与健康对照.
主要方法:
- 一项前性比较研究,涉及112名CRC患者和51名健康对照.
- 在受控条件下 (如饮食,吸烟) 收集出口气.
- 使用热吸附气色谱/质谱 (TD-GC/MS) 分析了53种挥发性有机化合物.
主要成果:
- 开发了四种预测模型,包括临床变量 (年龄,性别,饮食等). 和8种特定的VOCs.
- 模型显示出高的诊断性能:灵敏度 (84.0%98.2%),特异性 (89.2%93.8%),以及AUC (92.1%98.3%).
- 在CRC患者和对照人群之间观察到8种VOC水平的显著差异.
结论:
- 在结直肠癌患者和健康个体之间,呼出的VOC概况显著不同.
- 挥发性有机化合物和临床变量的综合模型显示,对于非侵入性CRC诊断具有很强的潜力.
- 需要进一步的研究,承认研究组之间的人口差异.
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