相关实验视频

Updated: May 24, 2025

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

[YARS1在肝细胞癌中的表达及其预后作用]

L H Hu¹, J Pan¹, H Cheng¹

¹Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China.

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

|March 5, 2025

概括

在肝细胞癌中,高表达的铁-tRNA合成酶1 (YARS1) 与预后较差相关. YARS1被确定为一个独立的预后因素,表明其作为肝癌治疗点的潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

肝细胞癌 (HCC) 是一个主要的全球健康问题,有效的治疗目标有限.
了解推动HCC进展的分子机制对于开发新型治疗策略至关重要.

研究的目的:

为了研究肝细胞癌中氨基-tRNA合成酶1 (YARS1) 的表达水平.
评估YARS1表达在HCC患者的预后意义.
探索与YARS1在HCC发育中的潜在分子途径.

主要方法:

利用癌症基因组图谱 (TCGA) 数据库分析374个HCC瘤样本和50个相邻的正常组织中的YARS1基因表达.
使用后勤回归,卡普兰-梅尔分析,日志等级测试和单变量/多变量考克斯回归来评估YARS1与临床特征和患者预后的相关性.
进行基因组丰富分析 (GSEA),以确定与HCC中YARS1相关的途径.

主要成果:

与正常组织相比,HCC组织中的YARS1表达显著更高 (P<0.001).
增加的YARS1表达与瘤等级相关 (P<0.05) 并与较差的生存率相关 (P<0.001).
多变量考克斯回归确定YARS1作为HC的独立预后因素 (HR=1.10,95% CI [1.050-1.156],P<0.001).

结论:

高YARS1表达与晚期肝细胞癌进展和不良预后有关.
YARS1成为预测HCC结果的潜在新生物标志物.
向YARS1可能是肝细胞癌治疗的有前途的治疗策略.

更多相关视频

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs

Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs

Published on: December 19, 2019

相关概念视频

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...