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Shawn Y Hsu¹, Eric J Kuo¹, Catherine McManus¹

¹Division of Endocrine Surgery, Department of Surgery, Columbia University Irving Medical Center, New York, New York, USA.

World journal of surgery

|March 5, 2025

概括

近红外自光谱 (NIRAF) 显示,与正常腺体相比,甲状腺腺瘤的比率较低. 然而,NIRAF尚未可靠地在手术期间区分不同的副甲状腺疾病.

科学领域:

内分泌手术内分泌手术
手术技术手术技术
医学诊断医学诊断医学诊断

背景情况:

近红外自光谱 (NIRAF) 是一种新兴的工具,用于在手术期间识别甲状腺腺.
它在区分正常细胞,超塑性和腺瘤性副甲状腺体之间的实用性尚未得到充分理解.
感应受体 (CaSR) 被假设为主要光体,被认为是在甲状腺腺瘤下调,可能导致较低的NIRAF比率.

研究的目的:

研究NIRAF光谱的潜力,以区分正常细胞,超塑性和腺状副甲状腺腺体.
为了确定NIRAF比率是否与副甲状腺病理相关.
评估使用NIRAF用于手术内甲状腺分化的可行性.

主要方法:

在接受甲状腺切除术或甲状腺切除术的患者中,对副甲状腺腺进行了手术内NIRAF比率的记录.
副甲状腺通过视觉检查被归类为正常细胞,并通过组织学证实 (超塑性或腺瘤性).
分析了44名患者的数据,其中包括137名确定的副甲状腺 (66名切除),分析了44名患者的数据.

主要成果:

与正常细胞副甲状腺相比,副甲状腺腺瘤的NIRAF中位数比率明显较低 (p=0.0005).
在正常细胞腺和超塑性腺之间 (p=0.35),或在超塑性腺和腺瘤之间 (p=0.04) 没有观察到中位NIRAF比率的显著差异.
接收器操作员特征分析表明,NIRAF光谱在对甲状腺病理的区分方面表现不佳.

结论:

虽然副甲状腺瘤的NIRAF比正常细胞腺体的比例较低,但NIRAF光谱目前的性能不足以在手术内可靠地区分各种副甲状腺病理.
在NIRAF比率中观察到的差异可能不足以用于临床决策.
在正常细胞腺体中,NIRAF比率最高,这表明其主要用途可能是识别正常的甲状腺组织.

关键词:

腺瘤腺瘤是一种自动光是一种自发光.过度增生症过度增生症接近红外线的近红外线.规范细胞的细胞.副甲状腺腺体是什么意思这是光谱学.

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