相关实验视频

Updated: May 24, 2025

Hyperpolarized Xenon for NMR and MRI Applications

Hyperpolarized Xenon for NMR and MRI Applications

Published on: September 6, 2012

超极化C代谢探针的临床翻译用于质瘤成像

Adam W Autry¹, Yaewon Kim¹, Duy Dang¹

¹From the Department of Radiology and Biomedical Imaging (A.W.A., Y.K., D.D., H.C., J.B.S., R.A.B., D.X., J.M.L., J.W.G., P.E.Z.L., D.B.V., Y.L.), Department of Neurological Surgery (D.B.V., S.M.C.), Department of Bioengineering and Therapeutic Sciences (D.B.V.) University of California San Francisco, San Francisco, CA, USA.

AJNR. American journal of neuroradiology

|March 5, 2025

概括

超极化碳-13 (HP-C) 核磁共振 (MRI) 提供了对质瘤的实时代谢洞察. 这种先进的成像技术显示出对非侵入性评估瘤负担,治疗反应和进展的前景.

科学领域:

医疗成像医学成像
生物化学生化学
在瘤学瘤学.

背景情况:

质瘤表现出代谢功能障碍,包括改变的三碳酸 (TCA) 循环路径.
传统的成像方法在评估瘤负担,治疗反应和疾病进展方面面临挑战.
超极化碳-13 (HP-C) 核磁共振利用增强的分子探针进行实时代谢评估.

研究的目的:

为了调查HP-CMRI的转化发展,用于质瘤成像.
为了突出HP探针生产中的创新,例如[1-13C]/[2-13C]-pyruvate和[1-13C,5-12C]-alpha-ketoglutarate.
为了证明这些探针在区分质瘤亚型和评估代谢途径方面的实用性.

主要方法:

使用溶解动态核极化 (d-DNP) 来增强C标签磁化.
作为非放射性代谢对比剂的HP探针 ([1-¹³C]/[2-¹³C]-pyruvate和[1-¹³C,5-¹²C]-alpha-ketoglutarate) 的使用.
采用先进的HP-CMRI硬件,采集和后处理技术,包括回声平面光谱成像 (EPSI).

主要成果:

HP-¹³C MRI 在质瘤中提供了取决于途径的代谢信息.
特定的探针在成像异酸脱酶 (IDH) 野生型质母细胞瘤和IDH突变质母细胞瘤中具有实用性.
示例数据说明了HP探头的目标功能和诊断潜力.

结论:

HP-¹³C MRI 是一种非侵入性质瘤评估的有前途的技术.
在HP探针生产方面的创新对于临床转化至关重要.
这种成像模式有望在质瘤管理中产生显著的翻译影响.

更多相关视频

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Published on: December 30, 2016

Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate

Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate

Published on: September 13, 2019

相关概念视频

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...

G-Protein Gated Ion Channels

G-Protein Gated Ion Channels

GPCRs are primarily responsible for our sense of smell, taste, and vision. The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...

Pore Transport and Ion-Pair Transport

Pore Transport and Ion-Pair Transport

Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...