多态学揭示了在衰老过程中积分细胞的代谢变化
Liangyue Shi1, Hengjie Wang2, Shuai Zhu2
1College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, China.
Cell proliferation
|March 5, 2025
概括
由于累积细胞中的分子变化,衰老会损害卵细胞的质量. 补充血清素 (5-HT) 改善了老化的卵细胞,为老年女性的生育治疗提供了洞察力.
科学领域:
- 生殖生物学 生殖生物学
- 老龄化的分子机制.
- 卵子质量和卵子细胞的发展.
背景情况:
- 母亲老龄化对卵细胞质量产生负面影响,但潜在的分子机制尚未完全理解.
- 积分细胞对于卵细胞发育至关重要,通过间隙结与卵细胞通信.
- 了解衰老中的累积细胞功能是解决与年龄相关的生育能力下降的关键.
研究的目的:
- 来自年轻和老年小鼠的累积细胞的蛋白质和代谢学概况的研究.
- 确定导致与年龄相关的卵细胞能力下降的分子机制.
- 探索潜在的治疗干预措施,以改善老年女性的卵细胞质量.
主要方法:
- 来自年轻和老老小鼠的累积细胞的蛋白质和代谢分析.
- 代谢途径的分析,包括脂肪酸β-氧化,核酸代谢和酸代谢 (氨酸合成和氨代谢).
- 在体外培养累积卵细胞复合物 (COCs) 与血清素 (5-HT) 补充剂,以评估其对老化卵细胞的影响.
主要成果:
- 衰老的累积细胞显示脂肪酸β-氧化和核酸代谢的活性增加,这表明补偿性能量供应.
- 在老化累积细胞中观察到降低了kynurenine代谢和显著降低了血清素 (5-HT) 合成.
- 在COC培养过程中补充5-HT可以改善老鼠卵细胞中的代谢功能障碍和 meiotic 缺陷.
结论:
- 综合的多omics数据揭示了累积细胞中与年龄相关的代谢变化.
- 衰老的累积细胞中血清素 (5-HT) 合成的减少有助于卵细胞的衰老.
- 中毒素 (5-HT) 补充剂是改善老年女性卵细胞质量和生育能力的潜在策略.
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