贝塔宁通过多个信号网络改善了脂聚糖引起的丸损伤
Fatime Geyikoglu1, Gulsah Yildiz Deniz2, Merve Arslan1
1Faculty of Sciences, Biology Deparment, Atatürk University, Erzurum, Turkey.
International journal of environmental health research
|March 5, 2025
概括
红甜菜中的贝他宁通过减少氧化应激,炎症和亡来保护丸免受败血症引起的丸损伤. 高剂量的贝宁补充剂改善了抗氧化酶活性,并抑制了大鼠的关键炎症途径.
科学领域:
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
- 自然产品化学 自然产品化学
背景情况:
- 败血症会对男性生殖系统产生负面影响.
- 氧化应激,炎症和亡是败血症引起的丸损伤的关键机制.
- 贝塔宁是红甜菜中的生物活性化合物,具有抗氧化和抗炎性质.
研究的目的:
- 在大鼠中研究贝塔宁对脂聚糖 (LPS) 诱导的丸损伤的保护作用.
- 评估贝塔宁对氧化应激,炎症,内质网膜 (ER) 应激和丸的亡的影响.
- 评估贝塔宁对托尔类受体4 (TLR4) 和核因子-卡帕B (NF-κB) 信号的调制.
主要方法:
- 雄性Sprague-Dawley大鼠被分为对照组,LPS诱导的败血症和贝他宁治疗组.
- 在LPS挑战诱导败血症模型之前,贝塔宁被口服.
- 评估的关键参数包括氧化应激标志物,炎症性细胞因子 (TNF,VCAM-1,MPO),ER应激标志物 (CHOP),亡标志物 (Bcl-2) 和TLR4/NF-κB表达.
主要成果:
- 高剂量的贝塔宁 (110毫克/公斤) 显著增强了超氧化物脱酶 (SOD) 活性,抵消了LPS诱导的氧化应激.
- 贝塔宁降低了炎症标志物 (TNF,VCAM-1,MPO) 的水平,并抑制了ER压力-CHOP通路.
- 贝塔宁降低了NF-κB和TLR4的表达,并增加了BCL-2的表达,表明了抗亡作用.
结论:
- 贝塔宁在老鼠中显示出显著的保护作用,防止LPS诱导的丸损伤.
- 贝塔宁通过减轻氧化应激,炎症和亡来减轻与败血症相关的丸损伤.
- 这些发现表明,贝塔宁作为毒症引起的生殖并发症的潜在治疗剂.
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