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Updated: May 24, 2025

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
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一个神秘的口袋在CB1驱动外围和功能选择性

Vipin Ashok Rangari1,2, Evan S O'Brien3,4, Alexander S Powers3,5,6,7

  • 1Center for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St. Louis, MO, USA.

Nature
|March 5, 2025
PubMed
概括

通过向外围受体,减少副作用和耐受性,新的大麻素受体1型 (CB1) 激动剂提供更安全的慢性疼痛缓解. 这种方法可以彻底改变疼痛治疗.

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Spare Receptors01:30

Spare Receptors

Some receptors remain unoccupied even when an agonist produces a maximal response. Such empty ones are called spare receptors. In presence of spare receptors the maximum effect of an agonist drug is achieved with fewer than 100% of the receptors being occupied. To determine the presence of spare receptors, scientists often compare the concentration of the drug needed to produce 50% of the maximum effect (EC50) with the concentration of the drug needed to occupy 50% of the receptors (Kd). If the...
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