在第一期精神病症中,自闭症有哪些特征? 来自两年后续研究的结果
Lorenzo Pelizza1,2, Antonio Federico3, Emanuela Leuci4
1Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum-Università di Bologna, Istituto di Psichiatria "Paolo Ottonello", Via Pepoli, 5, 40126, Bologna, Italy. lorenzo.pelizza@unibo.it.
概括
PANSS自闭症严重程度评分 (PAUSS) 在第一发精神病 (FEP) 中没有显示长期稳定性. 它确定了一个亚组,其症状严重程度较高,结果较差,受早期干预病例管理的影响.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 神经发育障碍 神经发育障碍
背景情况:
- PANSS自闭症严重程度评分 (PAUSS) 用于评估第一期精神病 (FEP) 中的自闭特征.
- 在FEP样本中对其纵向稳定性,过程和治疗反应的证据有限.
- 这项研究解决了在FEP纵向结果中更好地理解PAUSS的需求.
研究的目的:
- 在精神病早期干预 (EIP) 服务中,在2年内比较FEP患者的临床结果,有或没有"自闭症特征".
- 为了研究PAUSS得分和EIP治疗组件之间的关联.
- 评估PAUSS在FEP的纵向稳定性和预测有效性.
主要方法:
- 在2年内对301名FEP受试者进行了长度研究.
- 利用了积极和消极综合症量表 (PANSS),全球功能评估 (GAF) 和国家健康结果量表 (HoNOS).
- 采用了卡普兰-梅尔生存分析,混合设计ANOVA和多重线性后勤回归.
主要成果:
- 85名 (28.0%) FEP受试者得分超过了PAUSS截止线.
- 阳性PAUSS小组的症状和功能缓解率较低.
- PAUSS没有显示长期稳定性,而是显著减少,由病例管理会议预测.
结论:
- 停顿可能不是FEP中"特征类"自闭症特征的有效衡量标准.
- 它似乎识别出FEP的一个子组,具有更高的精神病理严重程度和更差的预后.
- 早期干预病例管理可能会影响FEP中PAUSS得分的变化.
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