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患有慢性病的患者接受不同的维生素D治疗时,周围脂肪有所不同:一项初步研究
Ana Checa-Ros1,2, Antonella Locascio3, Owahabanun-Joshua Okojie1
1Grupo de Investigación en Enfermedades Cardiorrenales y Metabólicas, Departamento de Medicina y Cirugía, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, 46115, Spain.
BMC nephrology
|March 5, 2025
概括
周周脂肪组织 (PAT) 厚度是慢性病 (CKD) 患者潜在的心血管疾病 (CVD) 风险因素,与其他维生素D类型相比,在接受 paricalcitol 治疗的患者中,其厚度降低了. 这表明维生素D类似物可能会影响CKD中的PAT积累.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
背景情况:
- 慢性病 (CKD) 与心血管疾病 (CVD) 和死亡率高相关.
- 慢性病患者表现出与骨和矿物质疾病 (BMD) 相关的独特心血管疾病风险因素,包括维生素D缺乏和二次性副甲状腺功能障碍.
- 体脂肪,包括围脂肪组织 (PAT),可能会导致CKD患者的心血管疾病风险.
研究的目的:
- 评估CKD患者中PAT的差异,CVD病史和维生素D受体激活剂治疗的差异.
- 探索PAT作为CKD中心血管疾病风险指标的潜在作用.
主要方法:
- 一项观察性研究涉及83名用维生素D或类似物治疗的CKD患者.
- 使用B模式超声波测量PAT厚度.
- 患者根据心血管疾病史和维生素D类比治疗 (胆卡西费醇,卡尔西醇,帕里卡尔西醇) 进行了分类.
主要成果:
- 与没有心血管疾病的患者相比,有心血管疾病史的患者表现出更高的尿素,尿酸,iPTH水平和更低的eGFR.
- 在有心血管病史的CKD患者中,平均PAT厚度显著更大 (0.99厘米),而不是那些没有 (0.80厘米) 的患者.
- 与接受胆结石醇或酸治疗的患者相比,接受结石醇治疗的患者显示PAT积累较少.
结论:
- 在CKD患者中,周周脂肪组织 (PAT) 厚度可能受到维生素D模拟疗法的影响.
- 与其他维生素D类似物相比,帕里卡尔西托尔可能与减少PAT积累有关.
- 需要进一步的研究来阐明在CKD中PAT,BMD和CVD之间的机制联系.
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