暴露于挥发性有机化合物和慢性呼吸道疾病死亡率,一个案例-队列研究
Mahdi Nalini1,2, Hossein Poustchi3, Deepak Bhandari4
1Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
像阿克罗莱因和烯这样的挥发性有机化合物 (VOC) 与慢性呼吸道疾病 (CRD) 的风险增加有关. 这项研究强调VOCs是CRD死亡率的重要环境风险因素.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 慢性呼吸道疾病 (CRD) 是全球主要的死亡原因.
- 有限的数据存在于挥发性有机化合物 (VOC) 和CRD死亡率在一般人群之间的关联.
- 挥发性有机物是常见的空气污染物和烟草烟雾的组成部分.
研究的目的:
- 调查特定的VOC代谢物与CRD死亡率之间的关联.
- 在一项大型队列研究中,评估VOCs作为CRD死亡率的潜在风险因素.
主要方法:
- 在戈勒斯坦队列研究 (n=50045) 中,采用了案例-队列研究设计.
- 参与者按年龄,性别,居住地和吸烟情况分层.
- 使用LC-MS/MS分析了20种VOC代谢物的基线尿样;使用Cox回归模型进行分析.
主要成果:
- 增加的CRD死亡率与较高的阿克罗莱因代谢产物 (HR 3.53; 95% CI 1.53-8.16) 和烯/乙代谢产物 (HR 3.24; 95% CI 1.37-7.66) 的三位数相关.
- 在排除了前四年的随访后,这些关联仍然很重要.
- 这项研究评估了149例CRD病例,持续了10.5年的随访.
结论:
- 这些发现支持VOC的呼吸道毒性,并表明烯和烯/乙烯是潜在的CRD危险因素.
- 建议对这些VOC进行进一步的研究和监测.
- 这项研究有助于了解环境暴露导致CRD死亡率的因素.
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