骨髓交感神经病变是血液形成性恶性瘤的标志,它涉及严重的超结构性损伤
Aurora Bernal1, Vincent Cuminetti1,2, Marc Serulla1
1Stem Cells, Ageing and Cancer Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, MH2 Building Level 10, 9019, Tromsø, Norway.
Experimental hematology & oncology
|March 5, 2025
概括
骨髓神经病变,包括交感神经损伤,在白血病和骨髓扩散性瘤等血液癌症中很普遍. 针对这种神经病变可能为这些疾病提供新的治疗策略.
科学领域:
- 血液学 血液学 血液学
- 神经科学是一个神经科学.
- 在瘤学瘤学.
背景情况:
- 骨髓 (BM) 中的造血干细胞 (HSC) 利基对于 HSC 调节至关重要.
- 交感神经纤维激活了BM,形成了造血干细胞和原生细胞 (HSPC) 利基的一部分.
- HSPC利基的神经病变与骨髓增殖性瘤 (MPN) 和急性髓性白血病 (AML) 的发展有关.
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