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在厌恶性记忆灭绝过程中,腹中前额叶皮层投射核的明显神经反应会使神经元团聚

Yuki Mochizuki^1,2, Asuka Joji-Nishino², Kazuo Emoto^3,4

¹Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.

Molecular brain

|March 5, 2025

概括

再聚 (RE) 和中脊 (MD) 丘脑向中间前额皮层 (mPFC) 投射,并参与厌恶性记忆灭绝. RE→mPFC神经元编码厌恶线索,但在灭绝过程中对行为变化没有必要.

科学领域:

神经科学是一个神经科学.
认知神经科学认知神经科学
行为神经科学行为神经科学

背景情况:

厌恶性记忆灭绝对于治疗焦虑障碍至关重要,它涉及边缘 thalamus 和中间前额叶皮层 (mPFC) 之间的相互作用.
虽然已知mPFC输入到边缘体丘脑调节记忆,但边缘体丘脑输出到mPFC的功能尚不清楚.

研究的目的:

调查聚会 (RE) 和中脊 (MD) 乳头核的角色,这些核向mPFC投射,在厌恶性记忆条件和灭绝中发挥作用.
阐明特定的thalamic efferent通路对mPFC在调节与恐惧相关行为的功能贡献.

主要方法:

在雄性小鼠中使用逆行追踪来绘制出向腹中中枢PFC (vmPFC) 和背中中枢PFC (dmPFC) 投射的RE和MD神经元的地形分离.
在厌恶性调节和灭绝范例期间,在RE→vmPFC和MD→vmPFC电路中使用纤维光度计记录神经元活动.
使用光遗传学来操纵这些神经元群体的活动并评估它们对结行为的影响.

主要成果:

在RE和MD thalamus中证明了vmPFC和dmPFC投射神经元的拓分离.
观察到,RE→vmPFC和MD→vmPFC神经元都对厌恶刺激做出反应,RE→vmPFC神经元在条件化过程中特别对冲击相关线索 (CS+) 产生反应.
发现在灭绝过程中,RE→vmPFC神经元对CS+表现出双相反应,而MD→vmPFC神经元没有表现出提示唤起的活动. 光遗传学操纵并没有改变与灭绝有关的结行为.

结论:

在恐惧记忆的灭绝过程中,RE→vmPFC神经元编码厌恶的提示信息.
这些RE→vmPFC神经元对于灭绝的行为调制是不可或缺的,这表明并行电路可能会驱动行为输出.
这项研究突出了边缘体丘脑-mPFC电路在处理厌恶记忆及其灭绝中的独特作用.

关键词:

厌恶性记忆是一种反感的记忆.灭绝的灭绝灭绝的灭绝背中部的 thalamic 核中背部的 thalamic 核再聚合了thalamic核的核心.

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