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Updated: May 24, 2025

Visualization and Quantification of Endogenous Intra-Organelle Protein Interactions at ER-Mitochondria Contact Sites by Proximity Ligation Assays
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Published on: October 20, 2023

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在神经退行性疾病中对VAPB-PTPIP51 ER-线粒体结合蛋白进行结构和功能研究

Kerry Blair1,2, Raquel Martinez-Serra1, Philippe Gosset1

  • 1Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England, U.K.

Acta neuropathologica communications
|March 5, 2025
PubMed
概括

细胞功能至关重要的内质网膜-线粒体信号传输在阿尔茨海默氏症和帕金森氏症等神经退行性疾病中受到干扰. 在这些条件下,对这种信号传输至关重要的VAPB-PTPIP51蛋白相互作用受到损害.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.肌缩性侧面硬化症 (AMLS) 是一种疾病.在前性痴呆症.神经退行性疾病的神经退行性疾病帕金森病是帕金森氏症的一种疾病.

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