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Updated: May 24, 2025

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在黑色素瘤细胞中,BRAFV600E-PROTAC与抑制剂对比:深度转录基因表征

Solomon O Alhassan1, Zakaria Y Abd Elmageed2, Youssef Errami3

  • 1Department of Gastrointestinal Oncology, Moffitt Cancer Center Magnolia Campus, Tampa, Florida, USA.

Clinical and translational medicine
|March 6, 2025
PubMed
概括

与传统抑制剂相比,针对BRAFV600E的新型蛋白质分解向化体 (PROTAC) 显示出优异的基因激活蛋白激酶 (MAPK) 信号抑制和减少黑色素瘤的早期耐药性.

关键词:
这就是BRAFV600E.通过MAPK路径.美国MITF MITF这就是PROTAC.不同化状态的分化状态.黑色素瘤是一种黑色素瘤.

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