通过饮食生物活性剂激活TGR5和相关的线粒体功能的改善,以缓解糖尿病和相关并发症
Quanrun He1,2, Xinhang Li1,2, Haimeng Li1,2
1School of Medicine, The Chinese University of Hong Kong, Shenzhen, 2001 Longxiang Boulevard, Longgang District, Shenzhen, Guangdong 518172, P.R. China.
Journal of agricultural and food chemistry
|March 6, 2025
概括
饮食化合物可以激活Takeda的G蛋白结合受体5 (TGR5),以帮助管理糖尿病. 本综述探讨了这些天然生物活性物及其机制如何为糖尿病及其并发症提供治疗潜力.
科学领域:
- 内分泌学和新陈代谢学
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 塔凯达G蛋白结合受体5 (TGR5),也称为GPBAR1,是葡萄糖恒温和能量代谢的关键调节者.
- TGR5激活越来越多地被认为是治疗糖尿病及其相关并发症的治疗潜力.
- 来自功能性食品和食用植物的食生物活性化合物正在成为TGR5.5的自然激活剂.
研究的目的:
- 综合审查饮食中的生物活性化合物在激活TGR5中对糖尿病管理的作用.
- 分析这些化合物调节TGR5活性的机制,包括直接的激动性和间接途径.
- 巩固在糖尿病治疗中用于治疗的饮食生物活性物对TGR5激活的分散研究.
主要方法:
- 对研究饮食中的生物活性和TGR5激活的研究进行系统文献综述.
- 对TGR5激活机制的分析,包括直接受体结合和间接调制.
- 探索间接途径,如肠道微生物群的改变和胆酸代谢的变化.
主要成果:
- 饮食中的生物活性化合物显示出作为TGR5激动剂的潜力,影响葡萄糖和能量代谢.
- 机制包括与TGR5的直接相互作用和通过肠道微生物群和胆酸池的间接调节.
- 有证据表明,天然化合物激活TGR5可能会减轻糖尿病并发症.
结论:
- 饮食中的生物活性物是TGR5向糖尿病治疗的有希望的途径.
- 了解TGR5激活的多方面的机制对于开发有效的干预措施至关重要.
- 对特定化合物及其临床疗效的进一步研究对于糖尿病管理是有必要的.
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