心血管疾病和痴呆的风险在一般人群中
Jiao Luo1, Ida Juul Rasmussen1, Børge G Nordestgaard2,3,4,5
1Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.
European journal of preventive cardiology
|March 6, 2025
概括
心血管疾病,特别是中风,可能与痴呆风险有因果关系. 对中风和缺血性心脏病的遗传易感性也增加了痴呆症的风险,突出了对综合预防策略的需要.
科学领域:
- 心血管流行病学心血管流行病学
- 神经退行性疾病 神经退行性疾病
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明,心血管疾病 (CVD) 与痴呆风险之间存在联系.
- 基因研究对这种关联产生了相互矛盾的结果.
- 调查因果关系对于有效预防痴呆症至关重要.
研究的目的:
- 确定9种特定的心血管疾病是否与全因痴呆症,阿尔茨海默病和血管痴呆症的风险有因果关系.
- 利用观测和遗传数据进行强大的因果推断.
主要方法:
- 在三个大型前性队列中进行了时间依赖的考克斯回归分析 (哥本哈根城市心脏研究,哥本哈根一般人口研究,英国生物银行).
- 单个参与者的数据进行了元分析.
- 用英国生物银行数据和FinnGen研究总结统计数据评估了对心脏病和痴呆风险的遗传易感性.
主要成果:
- 从观察上看,心血管疾病与所有痴呆症结局都有显著的关联.
- 在遗传上,对缺血性中风的易感性与所有原因痴呆症,阿尔茨海默病和血管痴呆症的风险增加有关.
- 对缺血性心脏病的遗传敏感性与血管痴呆风险有关.
结论:
- 脑卒中和痴呆 (所有原因,阿尔茨海默氏症,血管) 之间的关联可能是因果关系的.
- 对缺血性心脏病的遗传倾向是血管痴呆的危险因素.
- 将心血管疾病预防纳入痴呆症预防策略是必不可少的.
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