血清水平在儿童的脊柱仪器仪表后6岁及以上仍然较高
Peter J Cundy1, Georgia Antoniou2, Jennie Louise3
1Women's & Children's Hospital, University of Adelaide.
Journal of pediatric orthopedics
|March 6, 2025
概括
在脊柱植入手术后的六年内,儿童血液中的含量仍然很高. 和水平也显示出显著的变化,长期健康影响尚不清楚.
科学领域:
- 整形外科手术 整形外科手术
- 生物材料科学 生物材料科学
- 儿科健康 儿科健康
背景情况:
- 儿科脊柱植入物可以将循环的金属离子释放到体内.
- 以前的研究表明,手术后血清中,,和持续的含量升高.
研究的目的:
- 继续对接受脊柱形手术的儿童进行前性研究.
- 分析长期 (超过6年) 的循环金属离子水平,包括,,和.
主要方法:
- 展望性研究涉及34名参与者,在手术后6年内返回进行测试.
- 用于金属离子分析的高分辨率感应合等离子质谱仪.
- 线性混合效应模型用于分析随时间推移的血清水平,根据基线测量进行调整.
主要成果:
- 6年的水平中位数是手术前水平的2.40倍,尽管从2年的水平下降.
- 2年后的中位数含量显著增加,但在6年后与基线没有显著差异.
- 与基线相比,含量仍然很高,但与两年前的水平相比下降;含量没有显著变化.
结论:
- 在小儿脊柱仪器仪表后6年后,水平仍然明显高于基线.
- 金属离子沉积在器官中的长期健康影响和对后代的潜在影响尚不清楚.
- 在"全"结构中观察到的含量增加表明了潜在的金不规则.
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