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相关概念视频

DNA Microarrays02:34

DNA Microarrays

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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RNA-seq03:21

RNA-seq

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
9.8K
Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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相关实验视频

Updated: May 24, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
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STExplore:一个集成的在线平台,用于空间转录学数据的全面分析和可视化.

Yongtian Wang1,2,3,4, Jintian Luo5, Shaoqing Jiao5

  • 1School of Computer Science, Northwestern Polytechnical University, No.1 Dongxiang Road, Xi'an, Shaanxi, 710129, China.

Small methods
|March 6, 2025
PubMed
概括
此摘要是机器生成的。

STExplore是一个新的在线平台,分析来自各种技术的空间转录组数据. 它为基因表达,细胞组织和组织中的通信分析提供了完整的工作流.

关键词:
数据分析数据分析数据分析交互式可视化 交互式可视化一个单细胞RNA测序.空间转录学 空间转录学网络服务器是Web服务器.

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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
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Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

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相关实验视频

Last Updated: May 24, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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科学领域:

  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 空间转录组学将空间数据与基因表达用于组织分析.
  • 当前的平台面临着各种各样的技术,多omics集成和全面的工作流.
  • 解决这些局限性对于推进空间生物学研究至关重要.

研究的目的:

  • 开发STExplore,这是一个用于空间转录学分析的先进在线平台.
  • 为各种空间转录学技术提供统一和用户友好的解决方案.
  • 为了实现从预处理到细胞间通信研究的全面分析.

主要方法:

  • STExplore支持基于测序和基于图像的空间转录组学方法.
  • 该平台提供了一个完整的分析工作流:预处理,scRNA-seq集成,集群/基因层次分析和细胞-细胞通信.
  • 交互式可视化和动态参数调整整合在整个工作流中.

主要成果:

  • STExplore成功处理了用于神经发生,阿尔茨海默病和大脑组织架构的空间转录学数据.
  • 该平台展示了增强的基因表达分析,并揭示了细胞空间组织.
  • 组织内的细胞间通信模式被有效地揭露出来.

结论:

  • STExplore为空间转录学研究提供了一个全面,多功能和用户友好的平台.
  • 该平台为组织组织和细胞相互作用提供了更深入的见解.
  • STExplore解决了空间生物学领域日益增长的综合分析需求.