导出的中性粒细胞与淋巴细胞比率的诊断值,用于急性尾炎
Julio César Moreno-Alfonso1,2, Ada Molina Caballero2, Alberto Pérez Martínez2
1Doctoral School of Navarra, Universidad Pública de Navarra (UPNA), Pamplona, Spain.
ANZ journal of surgery
|March 6, 2025
概括
导出的中性粒细胞与淋巴细胞比率 (dNLR) 可以准确诊断儿童尾炎. 这种非侵入性生物标志物可以帮助识别需要进一步调查的病例,提高诊断准确度.
科学领域:
- 儿科医学 儿科医学
- 诊断生物标志物 诊断生物标志物
- 炎症标记物 炎症标记物
背景情况:
- 儿童尾炎的诊断带来了挑战,增加了并发症风险.
- 需要新的诊断工具来提高准确性和减少并发症.
研究的目的:
- 为了评估儿童尾炎中衍生的中性粒细胞与淋巴细胞比率 (dNLR) 的诊断价值.
- 评估dNLR作为儿科尾炎的辅助诊断工具.
主要方法:
- 一项诊断研究比较尾炎和非手术性腹痛 (AP) 的患者.
- 分析包括白细胞计数 (WBC),中性粒细胞与淋巴细胞比率 (NLR) 和dNLR.
- 从2020年至2022年期间入院的患者收集的数据.
主要成果:
- 纳入了202名儿科患者 (101名尾炎,101名AP).
- 在尾炎组中,白血球,NLR和dNLR显著更高 (P ≤ 0.0001).
- dNLR显示71%的灵敏度,74%的特异性,以及0.811的尾炎诊断的AUC.
结论:
- 导出的中性粒细胞与淋巴细胞比率 (dNLR) 是一种用于诊断尾炎的新型非侵入性生物标志物.
- dNLR具有很高的准确性,可以帮助在模两可的情况下做出临床决策.
- 一个dNLR值≥3.78表明进一步调查尾炎.
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