在自闭症谱系障碍和注意力缺陷多动性障碍中常见的肠道微生物特征
Zhifeng Cai1, Chao Che1, Dong Li1,2
1Department of Pediatrics, Shandong University Qilu Hospital, Jinan, Shandong, China.
概括
在患有自闭症谱系障碍 (ASD) 和注意力缺陷多动症障碍 (ADHD) 的儿童中,肠道微生物群的组成不同. 微生物特征可以将这些神经发育障碍与典型发育区分开来,提供诊断潜力.
科学领域:
- 微生物组研究的研究.
- 神经发育障碍 神经发育障碍
- 儿科卫生健康 儿科卫生健康
背景情况:
- 肠道微生物群在神经发育障碍 (如自闭症谱系障碍 (ASD) 和注意力缺陷多动症障碍 (ADHD) 中的作用正在调查中,但尚未完全理解.
- 患有自闭症和多动症儿童的特定微生物组成和功能需要进一步确定.
研究的目的:
- 分析和比较被诊断患有ASD,ADHD或两者的儿童的肠道微生物群组成和功能,与健康的对照对照.
- 确定可以区分神经发育障碍和典型发育之间的微生物特征.
主要方法:
- 16S rRNA测序在113名患有自闭症的儿童,43名患有多动症的儿童,8名患有两种疾病的儿童和120名健康对照组 (年龄为2至11岁) 的便样本上进行.
- 通过统计分析,根据临床诊断,年龄,并发症和其他因素,确定微生物组成,功能和网络结构的差异.
- 机器学习模型被用来评估肠道微生物特征的歧视力.
主要成果:
- 临床诊断,年龄,并发症,食物敏感性和抗生素使用是影响肠道微生物群的重要因素.
- 与对照人群相比,患有神经发育障碍的儿童表现出更大的微生物异质性和增加的Bifidobacterium丰度.
- 总共有4899个放松调节的微生物代谢功能被确定,以及患者中不同的基因级微生物网络.
- 在发现 (AUC:0.95-0.98) 和验证 (AUC:0.69-0.74) 组中,肠道微生物特征在区分患者和健康对照中表现出高准确度.
结论:
- 肠道微生物签名可以有效地将ASD和ADHD儿童与健康对照区分开来,这表明诊断潜力.
- 虽然ASD和ADHD共享一些肠道微生物特征,但不同的细菌物种及其代谢功能可能对疾病的发病有不同的贡献.
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