相关实验视频
Updated: May 24, 2025

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.5K
在患有"反射性甲状腺功能低下症"的患者中,使用每日剂量的levothyroxine吸收测试
Philippe Caron1, Charlotte Tudor1, Solange Grunenwald1
1Department of Endocrinology, Metabolic Diseases and Nutrition, Cardiovascular and Metabolic Unit, CHU Larrey, 31059 Toulouse, France.
Journal of the Endocrine Society
|March 6, 2025
概括
一个levothyroxine吸收测试有助于识别耐火性甲状腺功能低下症的原因,如吸收不良或不粘附. 这种耐受性良好的测试评估了口服牛甲状腺激素摄入后的甲状腺激素水平.
科学领域:
- 内分泌学 在内分泌学.
- 内部医学 内部医学
背景情况:
- 甲状腺功能低下是常见的,口服levothyroxine作为标准治疗.
- 超过15%的接受levothyroxine治疗的患者没有达到目标甲状腺刺激激素 (TSH) 水平.
- 耐火性甲状腺功能低下症可能源于吸收不良,增加甲状腺素代谢或不粘附.
研究的目的:
- 在耐火性甲状腺功能低下症患者中评估levothyroxine吸收测试的实用性.
- 要区分真正的吸收不良与不粘附或伪吸收不良.
- 为了评估levothyroxine吸收测试的耐受性和有效性.
主要方法:
- 在143名甲状腺功能低下患者中,进行了166次levothyroxine吸收测试.
- 患者持续高TSH水平尽管口服levothyroxine治疗被纳入.
- 血液样本在口服Levothyroxine摄入后的24小时内被采集,以测量总和自由T4水平.
主要成果:
- 耐火性甲状腺功能低下症与胃炎,H. pylori感染,药物相互作用,不坚持,乳病和减肥手术有关.
- 口服勒沃甲状腺素的摄入导致总和自由T4水平在4-6小时内显著增加.
- 甲素吸收测试耐受性良好,没有报告心血管不良事件.
结论:
- 甲状腺素吸收测试是诊断耐火性甲状腺功能低下症的原因的宝贵工具.
- 在服用勒沃西后4至6小时内评估T4水平,可以确认吸收.
- 这种测试是安全和有效的,用于区分在甲状腺功能低下症治疗失败的原因.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
4.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.1K
Methods for Studying Drug Absorption: In vitro
191
In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
191
Methods for Studying Drug Absorption: In situ
193
In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
193
Functions of Thyroid Hormones
2.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.5K
Bioavailability: Overview
2.6K
Bioavailability refers to the proportion of an unaltered drug that, after administration, enters the systemic circulation and can be distributed to the desired action site. Factors such as gastrointestinal (GI) absorption and liver biotransformation influence the bioavailability of a drug when it is administered orally. When a drug is administered intravenously, it enters the systemic circulation directly; by definition, its bioavailability is assumed to be 100%. The bioavailability of an...
2.6K

