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相关概念视频

Viral Structure00:56

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Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
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Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
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Updated: May 24, 2025

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
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病毒图:用于病毒整合分析和可视化的Web服务器.

Erqiang Hu1,2,3, Jianhong An1,2,3, Adam J Gersten1,4

  • 1Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States.

Frontiers in oncology
|March 6, 2025
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概括
此摘要是机器生成的。

病毒DNA整合到人类基因组中,通过引起基因组不稳定,驱动癌症. 我们开发了virusPlot,这是一个用于分析和可视化这些病毒集成站点的网络工具,为研究人员简化了复杂的数据.

关键词:
生物信息学工具 生物信息学工具计算生物学是计算生物学.基因组可视化 基因组可视化宿主-病毒相互作用.热点分析热点分析病毒整合 病毒整合

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科学领域:

  • 基因组学和生物信息学
  • 瘤学和病毒学

背景情况:

  • 病毒DNA融入人类基因组是癌症发展的关键因素,导致基因组不稳定性和改变基因表达.
  • 目前用于分析病毒整合的计算工具有限,特别是用于可视化和解释的基于Web的应用程序.

研究的目的:

  • 开发和介绍virusPlot,一个新的Web服务器,旨在分析和可视化病毒DNA集成到宿主基因组.
  • 为研究人员提供一个直观和用户友好的工具,以简化复杂的病毒整合模式的解释.

主要方法:

  • 开发了virusPlot作为一个使用shinyapp.pp.的交互式网络平台.
  • 实现了用于自动检索和注释病毒基因组序列的模块.
  • 综合可视化病毒和宿主基因组集成站点,读数,并使用费舍尔精确测试分析集成热点的分析.

主要成果:

  • VirusPlot成功地处理和可视化病毒整合数据,将病毒和宿主基因组整合站点连接起来.
  • 该工具有助于识别整合模式和热点.
  • 提供交互式图形表示,以便更轻松地解释集成数据.

结论:

  • VirusPlot解决了在病毒整合分析中需要专门的计算工具的需求.
  • 网络服务器为研究人员提供了一种高效和用户友好的解决方案,用于研究癌症发病的病毒宿主基因组相互作用.
  • 增强对病毒整合机制及其在癌症中的作用的理解.