在动脉切换手术后,中风体积是否会限制TGA患者的运动能力?
Renée S Joosen1, Michiel Voskuil2, Wieke G de Pater1
1Department of Pediatric Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
概括
在动脉切换手术 (ASO) 后的大动脉转移 (TGA) 患者的运动能力降低. 这可能是由于中风体积受损,影响运动期间的氧气吸收.
科学领域:
- 心脏病学 心脏病学
- 儿童心脏病学 儿童心脏病学
- 运动生理学 运动生理学
背景情况:
- 大动脉转移 (TGA) 是一种先天性心脏缺陷.
- 动脉切换手术 (ASO) 是TGA的常见手术修复.
- 患者经常经历ASO后的运动能力下降.
研究的目的:
- 评估中风体积在ASO后TGA患者运动能力降低中的作用.
- 在这个人群中确定与运动表现下降相关的因素.
主要方法:
- 对126名接受了TTE,CMR和CPET的TGA患者进行了回顾性分析.
- 患者按年龄分组 (<18岁和>=18岁).
- 运动能力降低,定义为氧气吸收峰值 (VO2峰值) Z-score < -2.2.
主要成果:
- 55%的成年TGA患者 (>=18岁) 显示VO2峰值降低,而儿童患者 (<18岁) 的这一比例为23%.
- 降低的VO2峰值与ASO,BMI,心率峰值和O2脉冲以来的时间独立相关.
- 在VO2峰值和O2脉冲 (R=0.621) 之间发现了强烈的相关性.
结论:
- 在TGA患者中,ASO后的运动能力可能受到增加中风体积的能力受损的限制.
- 成年TGA患者更有可能体验到运动能力下降.
- 在这个群体中,O2脉冲是运动能力的强有力的指标.
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