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相对脂肪量和胆结石之间的关联:基于NHANES 2017-2020年的横截面研究

Chaofeng Gao¹, Yanan Li², Xuan Ren³

¹Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, China.

Frontiers in nutrition

|March 6, 2025

概括

相对脂肪质量 (RFM) 是胆结石风险的更好的预测因素,而不是像BMI这样的传统措施. 这种新型指数可以帮助识别患胆结石病风险较高的人.

科学领域:

胃肠病学胃肠病学
公共卫生公共卫生
人类测量学人类测量学.

背景情况:

胆结石是一个重要的全球健康问题.
肥胖和脂肪分布是关键的危险因素,但传统的指标如BMI和腰围 (WC) 有局限性.
相对脂肪量 (RFM) 是一种新的指数,可以更好地预测胆结石风险.

研究的目的:

调查相对脂肪量 (RFM) 与胆结石形成风险之间的关联.
将RFM的预测性能与传统的人类指数 (BMI,WC等) 进行比较. ) 的情况.
开发和验证一个结合RFM的胆结石风险预测模型.

主要方法:

分析了2017-2020年NHANES研究中6,084名参与者 (年龄≥20岁) 的数据.
使用多变量逻辑回归和平滑曲线拟合来评估RFM-gallstone关联.
采用ROC分析,决策曲线分析 (DCA),LASSO和基于AIC的回归用于模型开发和验证.

主要成果:

每增加1个单位的RFM与11%更高的胆结石风险有关 (OR:1.11;95%CI:1.08-1.13).
观察到RFM和胆结石风险之间存在线性关系.
与BMI,WC,第一次世界大战和BRI相比,RFM显示出更高的预测能力 (AUC=0.705). 一个结合RFM,年龄,糖尿病,WC和酒精消费的开发模型实现了0.738.8的AUC.

结论:

相对脂肪量 (RFM) 与胆结石风险密切相关,并且在预测方面超过了传统措施.
开发的风险预测模型是识别高风险人群和指导干预的宝贵工具.
在临床和公共卫生方面,RFM显示出有希望的有效措施,以减轻胆结石疾病负担.

关键词:

尼汉斯 (NHANES) 是一个名人.跨截面研究是跨截面研究.胆结石胆结石胆结石肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖相对脂肪质量相对脂肪质量

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