心理学临床试验报告实践的系统审查:心理支持,治疗和心理社会干预
William Brennan1, Alex R Kelman2,3,4, Alexander B Belser1
1Consultants, New York, NY, USA.
Psychedelic medicine (New Rochelle, N.Y.)
|March 6, 2025
概括
迷幻的临床试验往往缺乏关于心理社会干预 (PI) 的详细报告. 改进这些报告实践对于标准化迷幻研究和提高治疗结果至关重要.
科学领域:
- 精神病学是一个精神病学.
- 心理学 心理学 心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 迷幻药辅助疗法在心理健康治疗方面越来越受到关注.
- 心理社会干预 (PI) 是迷幻治疗的关键组成部分,但往往报道很少.
- 缺乏标准化的报告阻碍了关于PI在迷幻治疗结果中的作用的经验明确性.
研究的目的:
- 系统地审查已发表的迷幻药物临床试验中心理干预措施的报告实践.
- 发现心理研究中报告PI的关键方面存在的缺陷.
- 为了比较心理测试中的报告标准与非心理测试中的报告标准.
主要方法:
- 自2000年以来出版的PubMed/Medline和PSYCinfo数据库对幻觉临床试验 (psilocybin,LSD,DMT,ayahuasca,MDMA) 的系统审查.
- 使用修改后的CONSORT扩展和TIDieR检查列表项进行分析.
- 包括关于精神病症候群的定量临床研究.
主要成果:
- 三十三项试验符合纳入标准,揭示了IP细节的严重报告不足.
- 主要缺陷包括:缺少33%的会话号码,45%的会话持续时间,42%的供应商凭证缺失,52%没有指定手册使用,54%没有引用可用手册,82%没有报告可靠性评估.
- 与非迷幻试验相比,迷幻试验报告显示报告不足.
结论:
- 在迷幻药临床试验中,心理社会干预措施的报道显著不足,需要改进.
- 加强报告实践对于研究标准化和优化迷幻药物治疗结果至关重要.
- 提供了建议,以改善PI报告在未来的迷幻研究.
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