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在T2DM患者中,使用MRI脂肪分数和R2*映射进行脏鼻腔脂肪功能障碍的初步定量分析

Yifan Dong¹, Qinhe Zhang¹, Xun Wang¹

¹Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.

Frontiers in endocrinology

|March 6, 2025

概括

脏鼻腔脂肪 (RSF) 脂肪分数 (FF) 独立地与2型糖尿病 (T2DM) 相关. 基于MRI的RSF FF和R2*映射可以帮助识别T2DM患者.

科学领域:

放射学放射学是一门学科.
医疗成像医学成像
内分泌学在内分泌学.

背景情况:

2型糖尿病 (T2DM) 是一种复杂的代谢障碍.
腎 sinus 脂肪 (RSF) 在代謝健康中起作用.
评估RSF功能障碍可能为T2DM病原体提供新的见解.

研究的目的:

在2型糖尿病 (T2DM) 患者中定量分析脏鼻腔脂肪 (RSF) 功能障碍.
使用磁共振成像 (MRI) 脂肪分数 (FF) 和R2*映射进行评估.
确定RSF特征与T2DM之间的关联.

主要方法:

186名住院患者 (38名T2DM,148名非T2DM) 接受了1.5T的腹部MRI.
测量的RSF体积,脂肪分数 (FF) 和R2*值.
使用后勤回归和ROC曲线分析来评估关联和诊断性能.

主要成果:

平均RSFFF和R2*与T2DM有显著的相关性.
平均RSFFF是T2DM的一个独立风险因素 (OR: 1.231).
RSF FF的AUC为0.701,R2*的AUC为0.616;综合AUC为0.729. 这两种组合的AUC均为0.729.

结论:

平均RSFFF是T2DM的独立预测因素.
通过脂肪细胞缩和改变铁沉积/缺氧表示的RSF功能障碍与T2DM有关.
基于MRI的RSF FF和R2*映射显示了T2DM诊断的潜力.

关键词:

脂肪功能障碍脂肪功能障碍磁共振成像技术的使用无线电标记器是一种放射标记器.脏鼻脂肪脏鼻脂肪 2型糖尿病是什么?

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Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...