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西斯普拉丁对听力的影响:使用PTA,高频听力测量,DPOAE和语音噪音测试的分析

Juhi Irfana Basheer¹, Ramaswamy Balakrishnan¹, Poorvi V Sharma¹

¹Department of ENT Kasturba Medical College, Manipal, Manipal Academy of Higher Education Manipal Karnataka India.

|March 6, 2025

概括

西斯普拉丁化疗可以导致听力损失,可通过高频纯音平均 (HFPTA) 和耳声发射 (DPOAEs) 检测. 语音噪声 (SPIN) 测试也显示性能降低,突出了癌症治疗期间需要听觉监测的需要.

科学领域:

耳毒性研究研究
癌症治疗副作用癌症治疗副作用
听力学和听力科学听力学和听力科学.

背景情况:

西斯是广泛用于各种癌症的化疗剂.
已知西斯普拉丁会引起耳毒性,导致听力损失.
早期发现西斯胺诱导的听力损失对于患者管理至关重要.

研究的目的:

为了评估在接受西斯普拉丁化疗的癌症患者的听力损失.
使用高频纯音调平均 (HFPTA),扭曲产品耳声排放 (DPOAEs) 和语音噪声 (SPIN) 测试进行耳毒性评估.
为了确定与西斯普拉丁诱导的听力损失相关的因素.

主要方法:

在第三级护理医院进行的前性研究.
包括预定接受西斯普拉丁化疗的患者.
在基线和化疗周期后进行了听觉评估 (HFPTA,DPOAE,SPIN). 分析了临床数据.

主要成果:

在随访期间,HFPTA检测到在高频率 (8-20 kHz) 上有显著的听力损失,尽管基线听力正常.
随着时间的推移,DPOAE显示负辐射增加,表明耳功能障碍.
随着治疗的进展,SPIN测试的性能下降;然而,与累积西斯普拉丁剂量的相关性是微弱的,并且对所有措施都不具有统计学意义.

结论:

综合性听力学监测,包括HFPTA,DPOAE和SPIN测试,对于早期检测西斯治疗患者的耳毒性至关重要.
在化疗期间需要定期进行听觉评估.
SPIN测试是监测化疗诱导的耳毒性的一种有价值和简单的工具.

关键词:

可持续发展目标3 SDG3 旋转旋转旋转听力测量听力测量仪西斯普拉丁 (cisplatin) 是一种制剂.听到听到听到听到听到听到听到耳毒性耳毒性耳毒性

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