伴随性疾病负担对全球左心功能的影响和心肌功能损伤的预测模型:心磁共振特征追踪研究
XiaoFeng Qu1, Miaomiao Bai1, Jianbo Lyu1
1Department of Radiology, The Second Hospital of Dalian Medical University, Dalian, China.
Frontiers in medicine
|March 6, 2025
概括
伴随性疾病负担,即使没有有机性心脏病,也会损害心脏功能. 这种负担,以及性别和葡萄糖水平,预测心脏损伤,使得在射出分数下降之前能够早期检测到.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 心血管疾病 心血管疾病
背景情况:
- 伴随性疾病,如高血压,糖尿病和脂质失调是普遍存在的.
- 评估这些患者的心脏功能至关重要,即使没有确诊的心脏病.
- 早期发现心肌功能障碍是预防不良结果的关键.
研究的目的:
- 研究并发症负担对没有有机心脏病的患者心肌功能的影响.
- 开发用于识别心肌功能损伤的预测模型.
- 评估心脏磁共振特征跟踪 (CMR-FT) 在这一群体中的实用性.
主要方法:
- 招募了82名健康人群和198名患有并发症负担 (高血压,T2DM,脂质失调) 的患者.
- 将患者根据并发症的数量 (<2和≥2) 分类为组.
- 使用CMR-FT测量左心房 (LA) 和左心室 (LV) 肌肉肌压力参数.
主要成果:
- 患有≥2并发症的患者显著减少LA储和导管应变.
- 在患有并发症负担 (<2和≥2) 的患者中,全球LV纵向和辐射应变均下降.
- 在≥2并发症组中,LV全球周围菌株减少. 伴随性疾病负担,男性性别,PBG和FBG预测了LV损伤 (AUC=0.848).
结论:
- 在LVEF下降之前,CMR-FT可以检测患有并发症负担的患者的亚临床心肌损伤.
- 伴随性疾病负担,性别和葡萄糖水平是LV心肌功能损伤的强有力的预测因素.
- 伴随性疾病负担和男性性别对LA心肌功能损伤具有预测价值.
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