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HER2-0和HER2-低乳腺癌的差异:作为预测因素的雄激素受体和编程死亡1

Xiaoqi Zhang^1,2, Ciqiu Yang¹, Yitian Chen¹

¹Department of Breast Cancer, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.

Journal of breast cancer

|March 6, 2025

概括

人类表皮生长因子受体2 (HER2) -低乳腺癌还不是一个独特的亚型. 雄激素受体 (AR) 表达和负编程死亡配体1 (PD-L1) 表达与乳腺癌患者的病理完整反应 (pCR) 率较低有关.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物研究生物标志物研究

背景情况:

人类表皮生长因子受体2 (HER2) -低乳腺癌正在作为一个独特的亚型进行研究.
以前比较HER2-低和HER2-0乳腺癌的研究缺乏共识.
在HER2-低乳腺癌中确定病理完整反应 (pCR) 的生物标志物至关重要.

研究的目的:

为了比较HER2-低和HER2-0乳腺癌之间的生存率和pCR率.
为了确定预测HER2-低乳腺癌患者pCR的生物标志物.

主要方法:

在三个中心对777名患者进行了回顾性分析.
分层分为HER2-低和HER2-0组.
对生存率和pCR率的比较,与使用二元物流分析的生物标志物调查.

主要成果:

HER2-0乳腺癌的pCR率明显高 (30.1%),高于HER2-低乳腺癌 (18.1%).
在HER2-低瘤中没有观察到显著的生存优势.
雄激素受体 (AR) 表达式预测了较差的pCR率 (OR,0.479),而编程死亡配体1 (PD-L1) 表达式预测了整体患者组的有利的pCR率 (OR,3.199).

结论:

目前没有足够的证据支持将HER2-低乳腺癌归类为一个独特的亚型.
AR表达与较低的pCR率有关.
负的PD-L1表达有助于降低乳腺癌中的pCR率.

关键词:

这是一种B7-H1抗原.乳腺新生体乳腺新生体接收器,ErbB-2 接收器接受器,雄激素受体

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