瘤细胞和状细胞典型的肺癌:不同的免疫表型和生物行为
Giovanna Sabella1, Giovanni Centonze1,2, Patrick Maisonneuve3
11st Pathology Division, Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
The journal of pathology. Clinical research
|March 6, 2025
概括
肺部典型癌细胞 (TCs) 有不同的组织学变异,包括瘤细胞和状细胞类型. 这些变异,与普通TC一起,显示出不同的临床病理特征和生存结果.
科学领域:
- 肺病理学 肺病理学
- 在瘤学瘤学.
- 组织病理学 组织病理学
背景情况:
- 肺部典型癌 (TCs) 是分化良好的神经内分泌瘤.
- 它们的蛋白质表达和与进展相关的形态学尚未得到充分理解.
- 瘤细胞和状细胞变体的临床意义一直在争论中.
研究的目的:
- 在大量的TC中识别瘤细胞和状细胞变体.
- 检查组织学变异和临床病理学特征之间的关联.
- 将这些变异与生存结果联系起来.
主要方法:
- 对297种肺部典型的癌类药物进行了中央审查.
- 瘤细胞和状细胞变体的识别.
- 对包括Ki-67在内的标记物的免疫组织化学分析.
- 与无疾病生存率 (DFS),总生存率和癌症特异性生存率 (CSS) 的相关性.
主要成果:
- 确定了瘤细胞TCs (12.1%) 和状细胞TCs (18.5%).
- 普通TC (69.4%) 显示,与瘤相关的死亡人数比变体更多 (p=0.01).
- 状细胞形态与较长的CSS (p=0.04) 有关.
- 组织学变异,年龄,瘤阶段和Ki-67预测了DFS.
结论:
- 肺部典型的癌体表现出不同的组织学变异:瘤细胞,状细胞和普通细胞.
- 这些变异与不同的临床病理学特征有关.
- 组织学亚型显著影响患者的治疗结果和生存率.
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