上腺查期间的益生素和上腺素
German Iñiguez1, Esteban Barnafi2, Enzo Lalli3,4,5
1Institute of Maternal and Child Research, Faculty of Medicine, University of Chile, Santiago, Chile.
Clinical endocrinology
|March 6, 2025
概括
女孩的过早上腺 (PremA) 与较高水平的上腺激素有关,特别是11氧化C19类固醇. 益生菌度与这些雄激素相关,这表明它可能在PremA发育中发挥作用.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 上腺类固醇生成 上腺类固醇生成
- 代谢健康 代谢健康
背景情况:
- 过早上腺 (PremA) 与增加脂肪,早期青春期和女孩的不良代谢状况有关.
- 最近的研究强调了11氧化C19类固醇的作用,这是由上腺产生强大的雄激素.
- 调节上腺11-氧化C19类固醇产生的机制尚不清楚,其中涉及到益生素受体变异.
研究的目的:
- 为了研究脱二三酸盐 (DHEAS) 和11-氧化C19类固醇度和青春期前女孩的益生菌水平之间的关联.
- 探索这些雄激素与早期上腺衰竭的潜在指标之间的关系.
主要方法:
- 在244名青春期前女孩中对DHEAS和11氧化C19类固醇进行LC-MS/MS分析.
- 根据第75个百分点,将女孩分为正常DHEAS (ND) 和高DHEAS (HD) 组.
- 对人类测量数据,益生菌和胰岛素水平的评估.
主要成果:
- 与ND女孩相比,HD女孩的体重,身高和BMI显著更高.
- 所有测量的11氧化C19类固醇 (11KA,11OHA,11KT,11OHT) 在HD组显著更高.
- 益生素水平与DHEAS无关,但与11KA有显著的正相关性,与11OHA有边缘关联.
结论:
- 11-基托 (11KT) 被证实是童年上腺和PremA.期间的主导生物活性雌激素.
- 益生素水平与上腺生物活性雄激素度直接相关.
- 童年时益生素水平升高可能在过早上腺癌的发展中起作用.
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