膀EpiCheck的临床实用性用于预测非肌肉侵入性膀癌的BCG反应
Fiorella L Roldán1,2, Mercedes Ingelmo-Torres1,2, Claudia Mercader1,2
1Laboratori i Servei d'Urologia, Hospital Clinic de Barcelona, Barcelona, Spain.
BJU international
|March 6, 2025
概括
膀Epicheck (BE) 有效预测非肌肉侵入性膀癌的复发和菌卡尔梅特-盖林 (BCG) 治疗失败. 后BCG结果和EpiScore变化识别高风险患者需要及时干预.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 分子诊断学 分子诊断
背景情况:
- 非肌肉侵入性膀癌 (NMIBC) 需要在治疗后进行有效的监测.
- Calmette-Guérin (BCG) 是NMIBC的标准静脉内免疫疗法.
- 预测复发和BCG治疗失败对于及时进行管理调整至关重要.
研究的目的:
- 评估膀经检 (BE) 在预测NMIBC复发方面的表现.
- 评估BE在诱导后的第一年内识别 Calmette-Guérin (BCG) 治疗失败的能力.
- 将BE的预测准确度与现有的风险分层工具进行比较.
主要方法:
- 对65名接受BCG治疗的NMIBC患者进行前性研究.
- 尿样被分析使用膀经检 (BE) 前和后BCG诱导.
- 后勤回归分析了临床变量,BE结果和结果之间的关联;开发了一个名图.
主要成果:
- 16.2%的患者经历了膀癌事件,其中68.8%是BCG失败 (高度复发).
- 后BCG囊镜,后BCGBE结果,以及前/后BCGEpiScore变化与复发和BCG失败有显著的相关性.
- 与CUETO风险表 (AUC 67.1%) 相比,结合这些因素的名图显示出更高的预测性能 (AUC 95.1%).
结论:
- 膀Epicheck (BE) 状态后BCG和EpiScore值变化对于早期识别患有膀癌事件和BCG失败高风险的患者非常有价值.
- 这些发现表明,BE可以显著影响NMIBC患者的疾病管理策略.
- 需要在更大,独立的队列中进一步验证.
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