热量尼斯塔格木斯强度的性别差异:应该更新参考值吗?
Johannes Gerb1,2, Sandra Becker-Bense1, Doreen Huppert1
1German Center for Vertigo and Balance Disorders (DSGZ), LMU University Hospital, LMU Munich, Munich, Germany.
Annals of the New York Academy of Sciences
|March 6, 2025
概括
双热热量测试揭示了 vestibular 反应性的基于性别的差异. 由于这些特定于性别的热量刺激性变异,目前的前庭性疾病诊断标准可能需要更新.
科学领域:
- 神经科学是一个神经科学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 诊断医学 诊断医学
背景情况:
- 双热热灌对于诊断外围前庭功能缺陷至关重要.
- 目前对单边前庭病变 (UVP),双边前庭病变 (BVP) 和前庭病变 (PVP) 的诊断标准使用性别中立的指标.
- 前庭功能中的性别特异可能会影响诊断的准确性.
研究的目的:
- 使用双热热灌数据分析总热活性 (TR) 的基于性别的差异.
- 评估这些差异对UVP,BVP和PVP诊断的影响.
- 确定当前的诊断标准是否需要修订,以考虑到性别特异性的变化.
主要方法:
- 来自德国和平衡障碍中心 (DSGZ) 的11332次热水热量检查的分析 (07/201801/2024).
- 计算总热量反应率 (TR) 和收集患者的年龄和性别.
- 应用UVP,BVP和PVP的国际诊断标准,分析绝对和相对指标.
主要成果:
- 与男性相比,女性的TR显著更高 (平均差异:6.41°/s,p<0.001).
- 使用绝对切断点对UVP,BVP和PVP的诊断显示男性占主导地位.
- 基于相对不对称的UVP诊断显示没有显著的性别差异 (OR -0.08,p = 0.06).
结论:
- 在热量刺激性方面存在显著的性别差异,女性表现出更高的TR.
- 目前对UVP,BVP和PVP的诊断标准依赖于绝对的热量刺激性,可能会产生偏见.
- 建议对诊断标准进行修订,以纳入性别特异的差异,以准确诊断前置障碍.
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