2022年印度尼西亚中爪地区从牛身上采集的块性皮肤病病毒的完整编码序列
Hendra Wibawa1, Lestari1, Toan Hong2
1Disease Investigation Centre Wates, Directorate General of Livestock and Animal Health Services, Ministry of Agriculture Indonesia, Yogyakarta, Indonesia.
Microbiology resource announcements
|March 6, 2025
概括
在印度尼西亚的牛群中发现了一种块性皮肤病病毒 (LSDV). 它的基因序列与来自东亚和东南亚的菌株密切相匹配,这表明潜在的区域传播.
科学领域:
- 兽医病毒学 兽医病毒学
- 分子流行病学分子流行病学
- 传染病监测 传染病监测 传染病
背景情况:
- 状皮肤病 (LSD) 是全球牛群的重大威胁.
- 在新地区出现和传播LSD病毒 (LSDV) 需要持续的遗传监测.
- 了解LSDV菌株的遗传相关性对于有效的疾病控制策略至关重要.
研究的目的:
- 报告一种新型块状皮肤病病毒 (LSDV) 隔离的完整编码序列.
- 为了确定印尼LSDV菌株的遗传血统和家族遗传关系.
- 为了解东南亚的LSDV流行病学做出贡献.
主要方法:
- 从受感染的牛中分离和测序块性皮肤病病毒 (LSDV).
- 全基因组测序以获得完整的编码序列.
- 用核酸序列数据进行基因分析,与已知的LSDV菌株进行比较.
主要成果:
- 2022年在印度尼西亚中央爪分离的LSDV菌株的完整编码序列已成功确定.
- 遗传学分析显示,印尼的LSDV分离物与2.5.5.分类内的菌株最为密切相关.
- 这一类物种此前在2019年至2021年期间在东亚和东南亚国家被发现.
结论:
- 这种LSDV菌株的遗传特征提供了有关其起源和潜在引入途径的宝贵数据.
- 与 2.5 类菌株的密切关系凸显了该地区LSDV 血统的持续流通和潜在传播.
- 持续的基因组监测对于监测LSDV演变和为区域生物安全措施提供信息至关重要.
更多相关视频
相关概念视频
01:10Retrovirus Life Cycles
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
01:16Viral Replication: Lysogenic Cycle
The lysogenic cycle is a crucial viral replication strategy that allows bacteriophages to persist within host cells without immediately destroying them. This process is primarily observed in temperate phages, such as bacteriophage lambda (λ), which infects Escherichia coli. The cycle allows the viral genome to persist across bacterial generations while keeping host cells viable.Integration of the Viral GenomeUpon infection, bacteriophage lambda attaches to the bacterial surface and injects its...
01:26Human Virome
The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
01:28Herpes
Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
01:28Rabies
Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
01:25Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...