微针辅助的黄素输送:评估针的长度和配方的影响
Em-On Chaiprateep1,2, Soma Sengupta1, Cornelia M Keck1
1Department of Pharmaceutics and Biopharmaceutics, Philipps-Universität Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany.
Micromachines
|March 6, 2025
概括
微针增强皮肤递送黄素,特别是作为纳米晶体. 即使是短的微针也有效地改善了溶解不良药物的皮肤透.
科学领域:
- 制药科学 制药科学
- 生物材料科学 生物材料科学
- 皮肤病学 皮肤病学
背景情况:
- 皮肤药物输送面临着库尔库等难溶化合物的挑战.
- 有效的皮肤透对于局部治疗疗效至关重要.
研究的目的:
- 用微针来评估黄素的皮肤透率.
- 为了比较黄素纳米晶体与通过微针传递的散装悬浮剂的疗效.
主要方法:
- 一个ex vivo猪耳朵模型被用来评估皮肤透.
- 使用0.25毫米,0.5毫米和1.0毫米长度的微针.
- 测试了黄素纳米晶体和散装悬浮剂.
主要成果:
- 所有微针配方都改善了黄素的穿越皮肤穿透.
- 与微针结合的库尔库纳米晶体显示出最高的透效率.
- 1.0毫米的微针提供了最佳的交付,更短的针也显示了显著的增强.
结论:
- 微针技术显著改善皮肤吸收难溶的黄素.
- 将纳米晶体配方与微针相结合,为增强局部药物输送提供了一个有希望的策略.
- 这种方法有可能改善局部黄素治疗的治疗结果.
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