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相关概念视频

Bioreactor Controls-II01:18

Bioreactor Controls-II

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In aerobic fermentations, oxygen is vital for microbial growth and metabolite production. Since air comprises only about 20% oxygen and the gas is poorly soluble in water—just 9 ppm at 20°C—supplying sufficient oxygen becomes a critical challenge, especially in high-demand processes like yeast growth or citric acid production. Even a fully saturated broth may offer only a few seconds of oxygen availability.To address this, sterile or scrubbed air is introduced into the...
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A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments
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一个多功能和模块化的微流体系统,用于动态细胞培养和细胞相互作用.

Qasem Ramadan1, Rana Hazaymeh2, Mohammed Zourob1

  • 1College of Science & General Studies, Alfaisal University, Riyadh 11533, Saudi Arabia.

Micromachines
|March 6, 2025
PubMed
概括

一个新的模块化微流体系统可以实现动态的细胞共同培养,允许灵活的安排来研究细胞-细胞相互作用和在生理相关的微环境中测试治疗方法.

科学领域:

  • 生物技术和生物医学工程 生物技术和生物医学工程
  • 细胞生物学 细胞生物学
  • 微流体学 微流体学

背景情况:

  • 开发先进的细胞培养模型对于理解复杂的生物系统至关重要.
  • 微流体设备可以精确控制细胞微环境.
  • 现有的共同文化系统往往缺乏模块化和动态重新配置能力.

研究的目的:

  • 开发一个多功能和模块化的微流体系统,用于动态细胞共同培养.
  • 为了使微流体芯片的灵活互连和重新配置,以研究细胞-细胞通信.
  • 评估系统在建模复杂的细胞相互作用和评估治疗药物的实用性.

主要方法:

  • 模块化微流体芯片的制造和组装,具有双隔间和多孔膜.
  • 集成流体,以精确调节流量.
  • 芯片的动态互连和重新配置,并行,串行和复杂的安排.
  • 肠上皮细胞和免疫细胞的共同培养,以模拟肠道屏障功能和炎症.
  • 通过穿越性皮质电阻和透度测量,评估上皮屏障完整性.
  • 刺激免疫细胞和检测炎症性细胞因子表达.

主要成果:

  • 成功开发并演示了一个模块化的微流体共同培养系统.
关键词:
制造 制造 制造 制造 制造整合 整合 整合 整合微流体学 在微流体学方面器官在芯片上的器官

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  • 灵活的芯片安排促进了动态的细胞间通信和空间操纵.
  • 该系统准确地模拟了肠上皮质屏障功能和炎症反应.
  • 穿体电阻和透性通过硫酸德克斯治疗来调节.
  • 在通过上皮层刺激免疫细胞时检测到炎症性细胞因子表达.

    • 结论:

    • 开发的微流体系统为先进的细胞共同培养提供了多功能和模块化的平台.
    • 它可以研究复杂的细胞相互作用和不同细胞排列的影响.
    • 该系统作为一种有价值的工具,用于研究疾病机制,并在生理学上相关的背景下选潜在的治疗药物.